Research workbench
T4 DNA polymerase fragment (residues 1-388) at 110K
Analyse T4 DNA polymerase fragment (residues 1-388) at 110K in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1NOZ
- Type
- protein
- Length
- 692 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA polymerase
- EC
- 2.7.7.7
- UniProt
- P04415
- Pockets
- 10 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | DNA polymerase (EC 2.7.7.7) | protein | 346 | 42% helix, 18% strand | P04415 |
Pockets
10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 364 | 0.62 | 0.78 | 27 | empty |
| 2 | 268 | 0.59 | 0.79 | 32 | empty |
| 3 | 105 | 0.58 | 0.85 | 21 | empty |
| 4 | 278 | 0.57 | 0.77 | 35 | empty |
| 5 | 208 | 0.55 | 0.78 | 31 | empty |
Interfaces
1 interface between chains.
- A–B · 1451 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 1NOZ · T4 DNA polymerase fragment (residues 1-388) at 110K · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04415
- Elsewhere: RCSB PDB 1NOZ · PDBe 1NOZ · UniProt P04415
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