MolNFT v1 · #160957 · protein
Crystal structure of the neuraminidase stabilization mutant Y169AH from A/SHANGHAI/2/2013 (H7N9)
6PZD: “Crystal structure of the neuraminidase stabilization mutant Y169AH from A/SHANGHAI/2/2013 (H7N9)”. X-ray diffraction, 4 ligands (MAN, NAG, BMA), 1 pocket (best druggability 0.62). MolNFT v1 #160957 on GenesisL1: 3D structure…
- PDB
- 6PZD
- Type
- protein
- Length
- 389 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Neuraminidase
- EC
- 3.2.1.18
- UniProt
- V9NZ28
- Ligands
- MAN, NAG, BMA, CA
- Pockets
- 1 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 4% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Neuraminidase (EC 3.2.1.18) | protein | 389 | 4% helix, 44% strand | V9NZ28 |
Ligands and binding sites
- MAN · alpha-D-mannopyranose · sugar · 7 copies
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains A
- BMA · beta-D-mannopyranose · sugar
- CA · Calcium ion · metal · chains A
- EDO · 1,2-ethanediol · additive · 5 copies · chains A
- MES · 2-(N-morpholino)-ethanesulfonic acid · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 271 | 0.62 | 0.81 | 42 | EDO |
Modifications
Observed in the structure: 9 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
- 6PZD · Crystal structure of the neuraminidase stabilization mutant Y169aH from A/Shanghai/2/2013… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt V9NZ28
- Elsewhere: RCSB PDB 6PZD · PDBe 6PZD · UniProt V9NZ28
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.