MolNFT v1 · #160865 · protein
MSCS DDM
6PWO · Small-conductance mechanosensitive channel: “MSCS DDM”. Electron microscopy, 20 pockets (best druggability 0.83). MolNFT v1 #160865 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6PWO
- Type
- protein
- Length
- 1,862 residues
- Chains
- 7
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Small-conductance mechanosensitive channel
- UniProt
- P0C0S1
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 1 distinct chain · 54% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G | Small-conductance mechanosensitive channel | protein | 266 | 54% helix, 22% strand | P0C0S1 |
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 318 | 0.83 | 0.92 | 28 | empty |
| 2 | 871 | 0.67 | 0.73 | 47 | empty |
| 3 | 111 | 0.61 | 0.86 | 21 | empty |
| 4 | 116 | 0.60 | 0.86 | 21 | empty |
| 5 | 122 | 0.60 | 0.85 | 20 | empty |
Interfaces
14 interfaces between chains.
- D–E · 2780 Ų buried · 24 hydrogen bonds · protein-protein
- C–D · 2778 Ų buried · 25 hydrogen bonds · protein-protein
- A–B · 2761 Ų buried · 23 hydrogen bonds · protein-protein
- B–C · 2751 Ų buried · 23 hydrogen bonds · protein-protein
- F–G · 2749 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0C0S1
- Elsewhere: RCSB PDB 6PWO · PDBe 6PWO · UniProt P0C0S1
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