PIE12 D-peptide against HIV entry (in complex with IQN17 Q577R resistance mutant)

Structure

x-ray diffraction · 2 distinct chains · 87% helix, 0% strand (DSSP).

Ligands and binding sites

• ACE · Acetyl group · ligand · 2 copies · chains H, A
• NH2 · Amino group · ion · 2 copies · chains H, A
• CL · Chloride ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• H–A · 351 Ų buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 15 d-amino, 2 covalent, 1 disulfide, 1 modified (D-amino acid, covalent ligand, disulfide, engineered).

Compared structures

• 6PSA · PIE12 D-peptide against HIV entry (in complex with IQN17 Q577R resistance mutant) · the same entry in another collection · chain H against H, TM-score 1.00
• P03069 · AlphaFold monomer V2.0 prediction for general control transcription factor GCN4 (P03069) · a predicted model of the same protein · chain A against A, TM-score 0.86

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P03069
• Every structure of UniProt P04578
• Elsewhere: RCSB PDB 6PSA · PDBe 6PSA · UniProt P03069 · UniProt P04578