MolNFT v1 · #160505 · protein

Trk-a in complex with ligand 1A

6PMC · High affinity nerve growth factor receptor: “Trk-a in complex with ligand 1A”. X-ray diffraction, 1 ligand (OQJ), 2 pockets (best druggability 0.76). MolNFT v1 #160505 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6PMC
Type: protein
Length: 289 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: High affinity nerve growth factor receptor
EC: 2.7.10.1
UniProt: P04629
Ligands: OQJ
Pockets: 2 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	High affinity nerve growth factor receptor (EC 2.7.10.1)	protein	289	42% helix, 20% strand	P04629

Ligands and binding sites

OQJ · N-(6-{[(5-chloro-2-methoxyphenyl)carbamoyl]amino}-1,3-benzothiazol-2-yl)benzamide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	675	0.76	0.81	57	OQJ
2	64	0.32	0.75	18	empty

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

6PMC · TRK-A IN COMPLEX WITH LIGAND 1a · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P04629
Elsewhere: RCSB PDB 6PMC · PDBe 6PMC · UniProt P04629

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