MolNFT v1 · #160293 · protein
WDR5DELTA23 bound to N-(4-(5-(hydroxymethyl)-1H-imidazol-2-YL)BUTYL) acetamide
6PG6 · Wd repeat-containing protein 5: “WDR5DELTA23 bound to N-(4-(5-(hydroxymethyl)-1H-imidazol-2-YL)BUTYL) acetamide”. X-ray diffraction, 3 ligands (OH7, SO4, CL), 2 pockets (best druggability 0.76). MolNFT v1 #160293 on GenesisL1: 3D…
- PDB
- 6PG6
- Type
- protein
- Length
- 605 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Wd repeat-containing protein 5
- UniProt
- P61964
- Ligands
- OH7, SO4, CL
- Pockets
- 2 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 0% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Wd repeat-containing protein 5 | protein | 301 | 0% helix, 51% strand | P61964 |
| B | Wd repeat-containing protein 5 | protein | 304 | 0% helix, 52% strand | P61964 |
Ligands and binding sites
- OH7 · N-{4-[4-(hydroxymethyl)-1H-imidazol-2-yl]butyl}acetamide · ligand · 2 copies · chains A, B
- SO4 · Sulfate ion · ion · 2 copies · chains A, B
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 659 | 0.76 | 0.81 | 64 | OH7, CL |
| 2 | 634 | 0.74 | 0.81 | 62 | SO4, OH7 |
Compared structures
- 6PG6 · WDR5delta23 bound to N-(4-(5-(hydroxymethyl)-1H-imidazol-2-yl)butyl)acetamide · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61964
- Elsewhere: RCSB PDB 6PG6 · PDBe 6PG6 · UniProt P61964
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.