MolNFT v1 · #160290 · protein
WDR5DELTA23 bound to (2-butyl-1H-imidazol-4-YL)METHANOL
6PG3 · Wd repeat-containing protein 5: “WDR5DELTA23 bound to (2-butyl-1H-imidazol-4-YL)METHANOL”. X-ray diffraction, 1 ligand (OHJ), 2 pockets (best druggability 0.76). MolNFT v1 #160290 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6PG3
- Type
- protein
- Length
- 600 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Wd repeat-containing protein 5
- UniProt
- P61964
- Ligands
- OHJ
- Pockets
- 2 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 0% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Wd repeat-containing protein 5 | protein | 300 | 0% helix, 51% strand | P61964 |
Ligands and binding sites
- OHJ · (2-butyl-1H-imidazol-4-yl)methanol · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 640 | 0.76 | 0.82 | 64 | OHJ |
| 2 | 634 | 0.75 | 0.81 | 66 | OHJ |
Compared structures
- 6PG3 · WDR5delta23 bound to (2-butyl-1H-imidazol-4-yl)methanol · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61964
- Elsewhere: RCSB PDB 6PG3 · PDBe 6PG3 · UniProt P61964
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