MolNFT v1 · #160204 · protein
Crystal structure of human protein arginine methyltransferase 9 (PRMT9)
6PDM · Protein arginine N-methyltransferase 9: “Crystal structure of human protein arginine methyltransferase 9 (PRMT9)”. X-ray diffraction, 1 ligand (UNX), 7 pockets (best druggability 0.70). MolNFT v1 #160204 on GenesisL1: 3D structure…
- PDB
- 6PDM
- Type
- protein
- Length
- 614 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein arginine N-methyltransferase 9
- EC
- 2.1.1.320
- UniProt
- Q6P2P2
- Ligands
- UNX
- Pockets
- 7 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 25% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein arginine N-methyltransferase 9 (EC 2.1.1.320) | protein | 614 | 25% helix, 34% strand | Q6P2P2 |
Ligands and binding sites
- UNX · Unknown atom or ion · ion · 13 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 535 | 0.70 | 0.80 | 52 | UNX |
| 2 | 333 | 0.68 | 0.82 | 39 | UNX |
| 3 | 122 | 0.63 | 0.87 | 27 | empty |
| 4 | 101 | 0.54 | 0.83 | 16 | empty |
| 5 | 97 | 0.38 | 0.76 | 17 | empty |
Compared structures
- 6PDM · Crystal structure of Human Protein Arginine Methyltransferase 9 (PRMT9) · the same entry in another collection · chain A against A, TM-score 1.00
- Q6P2P2 · AlphaFold monomer V2.0 prediction for protein arginine N-methyltransferase 9 (Q6P2P2) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6P2P2
- Elsewhere: RCSB PDB 6PDM · PDBe 6PDM · UniProt Q6P2P2
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