UniProt Q6P2P2
Protein arginine N-methyltransferase 9 (Q6P2P2)
Protein arginine N-methyltransferase 9 (UniProt Q6P2P2), EC 2.1.1.320: 6 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 34 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q6P2P2
- Protein
- Protein arginine N-methyltransferase 9
- EC
- 2.1.1.320
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 34 · 3 records with a druggable one
Structures
7 records of Q6P2P2 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6PDM | Crystal structure of human protein arginine methyltransferase 9 (PRMT9) | x-ray diffraction | A | UNX | — |
| 7RBQ | Co-crystal structure of human PRMT9 in complex with MT556 inhibitor | x-ray diffraction | A | 44T, UNX | 8 (best 0.73) |
| 7RBQ | Co-crystal structure of human PRMT9 in complex with MT556 inhibitor | x-ray diffraction | A | 44T, UNX | — |
| 7T39 | Co-crystal structure of human PRMT9 in complex with MT221 inhibitor | x-ray diffraction | A | EJB | 6 (best 0.73) |
| 7T39 | Co-crystal structure of human PRMT9 in complex with MT221 inhibitor | x-ray diffraction | A | EJB | — |
| 9AY9 | Co-crystal structure of human PRMT9 in complex with MRK-990 inhibitor | x-ray diffraction | A, B, C, D | A1AHM, UNX | 20 (best 0.80) |
| Q6P2P2 | AlphaFold monomer V2.0 prediction for protein arginine N-methyltransferase 9 (Q6P2P2) | predicted | A | — | — |
Ligands
- UNX · Unknown atom or ion · in 4 records
- 44T · 7-[5-S-(4-{[(4-ethylpyridin-3-yl)methyl]amino}butyl)-5-thio-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine · in 2 records
- EJB · 7-[5-S-(4-{[(2-ethylpyridin-3-yl)methyl]amino}butyl)-5-thio-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine · in 2 records
- A1AHM · 7-[5-S-(4-{[(2-tert-butylpyridin-3-yl)methyl]amino}butyl)-5-thio-beta-D-ribofuranosyl]-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine · in 1 record
Experiment against prediction
- 7T39 chain A against the predicted model Q6P2P2: TM-score 0.99, RMSD 0.99 Å
- 7T39 chain A against the predicted model Q6P2P2: TM-score 0.99, RMSD 0.99 Å
- 9AY9 chain C against the predicted model Q6P2P2: TM-score 0.99, RMSD 1.15 Å
- 9AY9 chain D against the predicted model Q6P2P2: TM-score 0.99, RMSD 1.15 Å
- 9AY9 chain A against the predicted model Q6P2P2: TM-score 0.99, RMSD 1.09 Å
- 7RBQ chain A against the predicted model Q6P2P2: TM-score 0.99, RMSD 1.07 Å
- 7RBQ chain A against the predicted model Q6P2P2: TM-score 0.99, RMSD 1.07 Å
- 6PDM chain A against the predicted model Q6P2P2: TM-score 0.99, RMSD 1.16 Å
- 9AY9 chain B against the predicted model Q6P2P2: TM-score 0.99, RMSD 1.25 Å
Elsewhere
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