MolNFT v1 · #160165 · protein + RNA
E. COLI 50S ribosome bound to compound 21
6PCH · 23S ribosomal RNA: “E. COLI 50S ribosome bound to compound 21”. Electron microscopy, 1 ligand (O8D), 20 pockets (best druggability 0.88). MolNFT v1 #160165 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6PCH
- Type
- protein + RNA
- Length
- 3,979 residues
- Chains
- 7
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 23S ribosomal RNA; 5S ribosomal RNA; 50S ribosomal protein L2; 50S ribosomal protein L15…
- UniProt
- P60422, A0A037Y8L6, D7Z9F6, P60438, D7ZET0
- Ligands
- O8D
- Pockets
- 20 · best druggability 0.88
Structure
electron microscopy · 7 distinct chains · 18% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| I | 23S ribosomal RNA | rna | 2897 | — | — |
| J | 5S ribosomal RNA | rna | 118 | — | — |
| K | 50S ribosomal protein L2 | protein | 271 | 8% helix, 25% strand | P60422 |
| L | 50S ribosomal protein L15 | protein | 144 | 22% helix, 11% strand | A0A037Y8L6 |
| M | 50S ribosomal protein L4 | protein | 201 | 33% helix, 12% strand | D7Z9F6 |
| N | 50S ribosomal protein L3 | protein | 206 | 6% helix, 33% strand | P60438 |
| O | 50S ribosomal protein L13 | protein | 142 | 32% helix, 18% strand | D7ZET0 |
Ligands and binding sites
- O8D · (3r,4r,5e,10e,12e,14s,26ar)-14-hydroxy-12-methyl-3-(propan-2-yl)-4-(prop-2-en-1-yl)-8,9,14,15,24,25,26, 26A-octahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-C][1, 8,4,19]dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetrone · ligand · chains I
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1085 | 0.88 | 0.91 | 111 | empty |
| 2 | 765 | 0.87 | 0.90 | 92 | empty |
| 3 | 1195 | 0.86 | 0.87 | 87 | empty |
| 4 | 1189 | 0.85 | 0.87 | 89 | empty |
| 5 | 948 | 0.84 | 0.87 | 73 | empty |
Interfaces
8 interfaces between chains.
- I–K · 7238 Ų buried · 175 hydrogen bonds · protein-nucleic
- I–N · 4887 Ų buried · 99 hydrogen bonds · protein-nucleic
- I–L · 4539 Ų buried · 100 hydrogen bonds · protein-nucleic
- I–M · 4172 Ų buried · 91 hydrogen bonds · protein-nucleic
- I–O · 2764 Ų buried · 53 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 21 modified (nucleotide modification).
Compared structures
- 6PCH · E. coli 50S ribosome bound to compound 21 · the same entry in another collection · chain I against I, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P60422
- Every structure of UniProt A0A037Y8L6
- Every structure of UniProt D7Z9F6
- Every structure of UniProt P60438
- Every structure of UniProt D7ZET0
- Elsewhere: RCSB PDB 6PCH · PDBe 6PCH · UniProt P60422 · UniProt A0A037Y8L6 · UniProt D7Z9F6 · UniProt P60438 · UniProt D7ZET0
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.