MolNFT v1 · #160069 · protein
Poliovirus 135S-like expanded particle in complex with a monoclonal antibody directed against the N-terminal extension of capsid protein VP1
6P9O: “Poliovirus 135S-like expanded particle in complex with a monoclonal antibody directed against the N-terminal…”. Electron microscopy, 8 pockets (best druggability 0.46). MolNFT v1 #160069 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6P9O
- Type
- protein
- Length
- 662 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- VP1; VP2; VP3
- UniProt
- P03300, Q8QYM4
- Pockets
- 8 · best druggability 0.46
Structure
electron microscopy · 3 distinct chains · 11% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| 1 | VP1 | protein | 201 | 11% helix, 39% strand | P03300 |
| 2 | VP2 | protein | 238 | 13% helix, 39% strand | P03300 |
| 3 | VP3 | protein | 223 | 8% helix, 32% strand | Q8QYM4 |
Pockets
8 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 122 | 0.46 | 0.78 | 25 | empty |
| 2 | 229 | 0.45 | 0.73 | 31 | empty |
| 3 | 107 | 0.44 | 0.78 | 21 | empty |
| 4 | 123 | 0.41 | 0.76 | 31 | empty |
| 5 | 89 | 0.38 | 0.76 | 20 | empty |
Interfaces
3 interfaces between chains.
- 1–3 · 2501 Ų buried · 37 hydrogen bonds · protein-protein
- 2–3 · 1693 Ų buried · 21 hydrogen bonds · protein-protein
- 1–2 · 1065 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6P9O · Poliovirus 135S-like expanded particle in complex with a monoclonal antibody directed… · the same entry in another collection · chain 1 against 1, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03300
- Every structure of UniProt Q8QYM4
- Elsewhere: RCSB PDB 6P9O · PDBe 6P9O · UniProt P03300 · UniProt Q8QYM4
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