MolNFT v1 · #159974 · protein

Crystal structure of voltage-gated sodium channel navab V100C/Q150C disulfide crosslinked mutant in the activated state

6P6Y · Ion transport protein: “Crystal structure of voltage-gated sodium channel navab V100C/Q150C disulfide crosslinked mutant in the…”. X-ray diffraction, 2 ligands (PX4, CPS), 2 pockets (best druggability 0.46). MolNFT v1 #159974 on…

PDB: 6P6Y
Type: protein
Length: 242 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ion transport protein
UniProt: A8EVM5
Ligands: PX4, CPS
Pockets: 2 · best druggability 0.46

Structure

x-ray diffraction · 1 distinct chain · 83% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ion transport protein	protein	242	83% helix, 0% strand	A8EVM5

Ligands and binding sites

PX4 · 1,2-dimyristoyl-sn-glycero-3-phosphocholine · ligand · 5 copies · chains A
CPS · 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate · ligand · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	127	0.46	0.78	20	empty
2	86	0.34	0.74	13	empty

Compared structures

6P6Y · Crystal structure of voltage-gated sodium channel NavAb V100C/Q150C disulfide crosslinked… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A8EVM5
Elsewhere: RCSB PDB 6P6Y · PDBe 6P6Y · UniProt A8EVM5

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.