MolNFT v1 · #159911 · protein
Structure of gadolinium-caged cobalt (III) insulin hexamer
6P4Z · Insulin chain a: “Structure of gadolinium-caged cobalt (III) insulin hexamer”. X-ray diffraction, 3 ligands (CO, GD, CL). MolNFT v1 #159911 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6P4Z
- Type
- protein
- Length
- 98 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin chain a; Insulin chain B
- UniProt
- P01308
- Ligands
- CO, GD, CL
Structure
x-ray diffraction · 3 distinct chains · 55% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Insulin chain a | protein | 21 | 67% helix, 10% strand | P01308 |
| B | Insulin chain B | protein | 30 | 47% helix, 13% strand | P01308 |
| D | Insulin chain B | protein | 26 | 54% helix, 12% strand | P01308 |
Ligands and binding sites
- CO · Cobalt (II) ion · metal · 2 copies · chains B, D
- GD · Gadolinium atom · metal · chains B
- CL · Chloride ion · ion · chains B, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
5 interfaces between chains.
- A–B · 877 Ų buried · 11 hydrogen bonds · protein-protein
- C–D · 732 Ų buried · 11 hydrogen bonds · protein-protein
- B–D · 606 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 56 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 45 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 6P4Z · Structure of gadolinium-caged cobalt (III) insulin hexamer · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 6P4Z · PDBe 6P4Z · UniProt P01308
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