MolNFT v1 · #159796 · protein

Crystal structure of EGFR with mutant-selective dihydrodibenzodiazepinone allosteric inhibitor

6P1D: “Crystal structure of EGFR with mutant-selective dihydrodibenzodiazepinone allosteric inhibitor”. X-ray diffraction, 3 ligands (ANP, NQ1, MG). MolNFT v1 #159796 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6P1D
Type: protein
Length: 1,196 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P00533
Ligands: ANP, NQ1, MG

Structure

x-ray diffraction · 4 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
D	—	protein	295	—	P00533
A	—	protein	309	—	P00533
B	—	protein	300	—	P00533
C	—	protein	292	—	P00533

Ligands and binding sites

ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · 4 copies · chains D, A, B, C
NQ1 · 10-benzyl-8-fluoro-5,10-dihydro-11H-dibenzo[b,e][1, 4]diazepin-11-one · ligand · 3 copies · chains D, B, C
MG · Magnesium ion · metal · 4 copies · chains D, A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6P1D · Crystal structure of EGFR with mutant-selective dihydrodibenzodiazepi allosteric inhibitor · the same entry in another collection · chain C against C, TM-score 1.00
P00533 · AlphaFold monomer V2.0 prediction for epidermal growth factor receptor (P00533) · a predicted model of the same protein · chain C against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00533
Elsewhere: RCSB PDB 6P1D · PDBe 6P1D · UniProt P00533

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.