MolNFT v1 · #159745 · protein
Crystal structure of the MIF4G domain of trypanosoma cruzi translation initiation factor EIF4G5
6OZU · Eukaryotic translation initiation factor 4 gamma 5: “Crystal structure of the MIF4G domain of trypanosoma cruzi translation initiation factor EIF4G5”. X-ray diffraction, 1 ligand (SO4), 4 pockets (best druggability 0.69). MolNFT v1…
- PDB
- 6OZU
- Type
- protein
- Length
- 469 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 4 gamma 5
- UniProt
- A0A2V2WAU2
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 73% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation factor 4 gamma 5 | protein | 235 | 74% helix, 0% strand | A0A2V2WAU2 |
| B | Eukaryotic translation initiation factor 4 gamma 5 | protein | 234 | 73% helix, 0% strand | A0A2V2WAU2 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 271 | 0.69 | 0.85 | 45 | GOL |
| 2 | 97 | 0.52 | 0.83 | 22 | GOL |
| 3 | 72 | 0.44 | 0.81 | 21 | SO4 |
| 4 | 86 | 0.34 | 0.74 | 14 | GOL |
Interfaces
1 interface between chains.
- A–B · 2345 Ų buried · 30 hydrogen bonds · protein-protein
Compared structures
- 6OZU · Crystal structure of the MIF4G domain of Trypanosoma cruzi translation initiation factor… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A2V2WAU2
- Elsewhere: RCSB PDB 6OZU · PDBe 6OZU · UniProt A0A2V2WAU2
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.