Research workbench
Crystal structure of the MIF4G domain of trypanosoma cruzi translation initiation factor EIF4G5
Analyse Crystal structure of the MIF4G domain of trypanosoma cruzi translation… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6OZU
- Type
- protein
- Length
- 469 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 4 gamma 5
- UniProt
- A0A2V2WAU2
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 73% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation factor 4 gamma 5 | protein | 235 | 74% helix, 0% strand | A0A2V2WAU2 |
| B | Eukaryotic translation initiation factor 4 gamma 5 | protein | 234 | 73% helix, 0% strand | A0A2V2WAU2 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 271 | 0.69 | 0.85 | 45 | GOL |
| 2 | 97 | 0.52 | 0.83 | 22 | GOL |
| 3 | 72 | 0.44 | 0.81 | 21 | SO4 |
| 4 | 86 | 0.34 | 0.74 | 14 | GOL |
Interfaces
1 interface between chains.
- A–B · 2345 Ų buried · 30 hydrogen bonds · protein-protein
Compared structures
- 6OZU · Crystal structure of the MIF4G domain of Trypanosoma cruzi translation initiation factor… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A2V2WAU2
- Elsewhere: RCSB PDB 6OZU · PDBe 6OZU · UniProt A0A2V2WAU2
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