MolNFT v1 · #159709 · protein
The structure of the PP2A B56 subunit KIF4A complex
6OYL · SERINE/THREONINE-protein phosphatase 2A 56 kda regulatory…: “The structure of the PP2A B56 subunit KIF4A complex”. X-ray diffraction, 3 pockets (best druggability 0.60). MolNFT v1 #159709 on GenesisL1: 3D structure, binding sites…
- PDB
- 6OYL
- Type
- protein
- Length
- 335 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein phosphatase 2A 56 kda regulatory subunit gamma isoform…
- UniProt
- Q13362, O95239
- Pockets
- 3 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 69% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein phosphatase 2A 56 kda regulatory subunit gamma isoform | protein | 323 | 72% helix, 0% strand | Q13362 |
| B | Chromosome-associated kinesin KIF4A | protein | 12 | 0% helix, 0% strand | O95239 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 64 | 0.60 | 0.90 | 16 | empty |
| 2 | 106 | 0.39 | 0.75 | 17 | empty |
| 3 | 53 | 0.29 | 0.75 | 10 | empty |
Interfaces
1 interface between chains.
- A–B · 776 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 6OYL · The structure of the PP2A B56 subunit KIF4A complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q13362 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase 2A 56 kda… · a predicted model of the same protein · chain A against A, TM-score 0.95
- O95239 · AlphaFold monomer V2.0 prediction for chromosome-associated kinesin KIF4A (O95239) · a predicted model of the same protein · chain B against A, TM-score 0.33
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13362
- Every structure of UniProt O95239
- Elsewhere: RCSB PDB 6OYL · PDBe 6OYL · UniProt Q13362 · UniProt O95239
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