MolNFT v1 · #159669 · protein
Crystal structure of the complex between the type VI effector TAS1 and its immunity protein
6OX6: “Crystal structure of the complex between the type VI effector TAS1 and its immunity protein”. X-ray diffraction, 3 pockets (best druggability 0.69). MolNFT v1 #159669 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6OX6
- Type
- protein
- Length
- 270 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TAS1; PA14_01140
- UniProt
- A0A232D9K2, A0A090A233
- Pockets
- 3 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TAS1 | protein | 194 | 52% helix, 15% strand | A0A232D9K2 |
| B | PA14_01140 | protein | 76 | 30% helix, 28% strand | A0A090A233 |
Ligands and binding sites
- ACT · Acetate ion · additive · 7 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 404 | 0.69 | 0.81 | 47 | ACT |
| 2 | 120 | 0.42 | 0.76 | 23 | empty |
| 3 | 55 | 0.24 | 0.72 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1376 Ų buried · 27 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (engineered).
Compared structures
- 6OX6 · Crystal structure of the complex between the Type VI effector Tas1 and its immunity… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A232D9K2
- Every structure of UniProt A0A090A233
- Elsewhere: RCSB PDB 6OX6 · PDBe 6OX6 · UniProt A0A232D9K2 · UniProt A0A090A233
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