MolNFT v1 · #159602 · protein
The crystal structure of the isolate tryptophan synthase alpha-chain from salmonella enterica serovar typhimurium at 1.60 ångström resolution
6OUY · Tryptophan synthase alpha chain: “The crystal structure of the isolate tryptophan synthase alpha-chain from salmonella enterica serovar…”. X-ray diffraction, 2 ligands (SO4, CL), 5 pockets (best druggability 0.56). MolNFT v1 #159602…
- PDB
- 6OUY
- Type
- protein
- Length
- 258 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tryptophan synthase alpha chain
- EC
- 4.2.1.20
- UniProt
- P00929
- Ligands
- SO4, CL
- Pockets
- 5 · best druggability 0.56
Structure
x-ray diffraction · 1 distinct chain · 52% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tryptophan synthase alpha chain (EC 4.2.1.20) | protein | 258 | 52% helix, 13% strand | P00929 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 6 copies · chains A
- CL · Chloride ion · ion · chains A
- DMS · Dimethyl sulfoxide · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 82 | 0.56 | 0.86 | 18 | DMS |
| 2 | 191 | 0.49 | 0.76 | 26 | SO4, CL |
| 3 | 70 | 0.32 | 0.75 | 20 | empty |
| 4 | 69 | 0.29 | 0.73 | 18 | SO4 |
| 5 | 74 | 0.27 | 0.71 | 15 | empty |
Compared structures
- 6OUY · The crystal structure of the isolate tryptophan synthase alpha-chain from Salmonella… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00929
- Elsewhere: RCSB PDB 6OUY · PDBe 6OUY · UniProt P00929
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