MolNFT v1 · #159600 · protein
1-deoxy-D-xylulose 5-phosphate synthase (dxps) from deinococcus radiodurans with enamine intermediate bound
6OUW · 1-deoxy-D-xylulose-5-phosphate synthase: “1-deoxy-D-xylulose 5-phosphate synthase (dxps) from deinococcus radiodurans with enamine intermediate bound”. X-ray diffraction, 3 ligands (HTL, MG, NA), 1 pocket (best druggability 0.66).…
- PDB
- 6OUW
- Type
- protein
- Length
- 544 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 1-deoxy-D-xylulose-5-phosphate synthase
- EC
- 2.2.1.7
- UniProt
- Q9RUB5
- Ligands
- HTL, MG, NA
- Pockets
- 1 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 1-deoxy-D-xylulose-5-phosphate synthase (EC 2.2.1.7) | protein | 544 | 41% helix, 18% strand | Q9RUB5 |
Ligands and binding sites
- HTL · 2-acetyl-thiamine diphosphate · ligand · chains A
- MG · Magnesium ion · metal · chains A
- NA · Sodium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 497 | 0.66 | 0.77 | 50 | HTL, MG |
Compared structures
- 6OUW · 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Deinococcus radiodurans with enamine… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9RUB5 · AlphaFold monomer V2.0 prediction for 1-deoxy-D-xylulose-5-phosphate synthase (Q9RUB5) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9RUB5
- Elsewhere: RCSB PDB 6OUW · PDBe 6OUW · UniProt Q9RUB5
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.