MolNFT v1 · #159542 · protein
Potent and selective antitumor antibody targeting a membrane-proximal epitope of ROR2
6OSV · Antibody light chain variable region: “Potent and selective antitumor antibody targeting a membrane-proximal epitope of ROR2”. X-ray diffraction, 3 pockets (best druggability 0.44). MolNFT v1 #159542 on GenesisL1: 3D structure…
- PDB
- 6OSV
- Type
- protein
- Length
- 311 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Antibody light chain variable region; Tyrosine-protein kinase transmembrane receptor…
- EC
- 2.7.10.1
- UniProt
- Q01974
- Pockets
- 3 · best druggability 0.44
Structure
x-ray diffraction · 3 distinct chains · 7% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Antibody light chain variable region | protein | 111 | 3% helix, 48% strand | — |
| K | Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) | protein | 81 | 7% helix, 19% strand | Q01974 |
| H | Antibody heavy chain variable region | protein | 119 | 10% helix, 54% strand | — |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 115 | 0.44 | 0.78 | 26 | empty |
| 2 | 65 | 0.28 | 0.73 | 22 | empty |
| 3 | 50 | 0.26 | 0.74 | 18 | empty |
Interfaces
3 interfaces between chains.
- L–H · 921 Ų buried · 10 hydrogen bonds · protein-protein
- L–K · 491 Ų buried · 12 hydrogen bonds · protein-protein
- K–H · 387 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 6OSV · Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2 · the same entry in another collection · chain L against L, TM-score 1.00
- Q01974 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase transmembrane receptor ROR2… · a predicted model of the same protein · chain K against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q01974
- Elsewhere: RCSB PDB 6OSV · PDBe 6OSV · UniProt Q01974
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