MolNFT v1 · #159533 · protein
Cryo-EM structure of the N-terminally acetylated full length alpha- synuclein fibrils (AC1-140)
6OSJ · Alpha-synuclein: “Cryo-EM structure of the N-terminally acetylated full length alpha- synuclein fibrils (AC1-140)”. Electron microscopy, 6 pockets (best druggability 0.73). MolNFT v1 #159533 on GenesisL1: 3D structure, binding sites…
- PDB
- 6OSJ
- Type
- protein
- Length
- 610 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-synuclein
- UniProt
- P37840
- Pockets
- 6 · best druggability 0.73
Structure
electron microscopy · 1 distinct chain · 0% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J | Alpha-synuclein | protein | 61 | 0% helix, 46% strand | P37840 |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 430 | 0.73 | 0.84 | 47 | empty |
| 2 | 424 | 0.73 | 0.84 | 45 | empty |
| 3 | 423 | 0.58 | 0.75 | 31 | empty |
| 4 | 392 | 0.57 | 0.74 | 31 | empty |
| 5 | 96 | 0.32 | 0.73 | 29 | empty |
Interfaces
24 interfaces between chains.
- E–G · 2299 Ų buried · 68 hydrogen bonds · protein-protein
- C–E · 2287 Ų buried · 66 hydrogen bonds · protein-protein
- D–F · 2283 Ų buried · 69 hydrogen bonds · protein-protein
- F–H · 2282 Ų buried · 68 hydrogen bonds · protein-protein
- B–D · 2281 Ų buried · 68 hydrogen bonds · protein-protein
Compared structures
- 6OSJ · Cryo-EM structure of the N-terminally acetylated full length alpha-synuclein fibrils… · the same entry in another collection · chain F against F, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37840
- Elsewhere: RCSB PDB 6OSJ · PDBe 6OSJ · UniProt P37840
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.