MolNFT v1 · #15942 · protein
NK1 fragment of human hepatocyte growth FACTOR/SCATTER factor (HGF/SF) at 2.5 ångström resolution
1NK1 · Protein (hepatocyte growth factor precursor): “NK1 fragment of human hepatocyte growth FACTOR/SCATTER factor (HGF/SF) at 2.5 ångström resolution”. X-ray diffraction, 5 pockets (best druggability 0.69). MolNFT v1 #15942 on GenesisL1…
- PDB
- 1NK1
- Type
- protein
- Length
- 344 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (hepatocyte growth factor precursor)
- UniProt
- P14210
- Pockets
- 5 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 9% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Protein (hepatocyte growth factor precursor) | protein | 172 | 9% helix, 31% strand | P14210 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 445 | 0.69 | 0.80 | 47 | empty |
| 2 | 214 | 0.56 | 0.79 | 30 | empty |
| 3 | 132 | 0.45 | 0.77 | 29 | empty |
| 4 | 133 | 0.45 | 0.77 | 24 | empty |
| 5 | 84 | 0.38 | 0.77 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1192 Ų buried · 21 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 1NK1 · NK1 fragment of human hepatocyte growth FACTOR/SCATTER factor (HGF/SF) at 2.5 ångström… · the same entry in another collection · chain A against A, TM-score 1.00
- P14210 · AlphaFold monomer V2.0 prediction for hepatocyte growth factor (P14210) · a predicted model of the same protein · chain A against A, TM-score 0.59
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14210
- Elsewhere: RCSB PDB 1NK1 · PDBe 1NK1 · UniProt P14210
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