MolNFT v1 · #159306 · protein
Protein tyrosine phosphatase 1B (1-301), F182A mutant, apo state
6OL4 · Tyrosine-protein phosphatase non-receptor type 1: “Protein tyrosine phosphatase 1B (1-301), F182A mutant, apo state”. X-ray diffraction, 2 pockets (best druggability 0.44). MolNFT v1 #159306 on GenesisL1: 3D structure, binding sites…
- PDB
- 6OL4
- Type
- protein
- Length
- 296 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein phosphatase non-receptor type 1
- EC
- 3.1.3.48
- UniProt
- P18031
- Pockets
- 2 · best druggability 0.44
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) | protein | 296 | 37% helix, 21% strand | P18031 |
Ligands and binding sites
- GOL · Glycerol · additive · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 140 | 0.44 | 0.76 | 19 | empty |
| 2 | 52 | 0.30 | 0.76 | 14 | empty |
Modifications
Observed in the structure: 1 modified (oxidation).
Compared structures
- 6OL4 · Protein Tyrosine Phosphatase 1B (1-301), F182A mutant, apo state · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18031
- Elsewhere: RCSB PDB 6OL4 · PDBe 6OL4 · UniProt P18031
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