MolNFT v1 · #159125 · protein
Crystal structure of the CRY1-PER2 complex
6OF7 · Cryptochrome-1: “Crystal structure of the CRY1-PER2 complex”. X-ray diffraction, 8 pockets (best druggability 0.69). MolNFT v1 #159125 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6OF7
- Type
- protein
- Length
- 555 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cryptochrome-1; Period circadian protein homolog 2
- UniProt
- P97784, O15055
- Pockets
- 8 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cryptochrome-1 | protein | 472 | 45% helix, 7% strand | P97784 |
| B | Period circadian protein homolog 2 | protein | 83 | 39% helix, 0% strand | O15055 |
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 470 | 0.69 | 0.79 | 33 | empty |
| 2 | 261 | 0.62 | 0.80 | 35 | empty |
| 3 | 65 | 0.49 | 0.85 | 18 | empty |
| 4 | 103 | 0.41 | 0.76 | 18 | empty |
| 5 | 111 | 0.40 | 0.75 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 2721 Ų buried · 27 hydrogen bonds · protein-protein
Compared structures
- 6OF7 · Crystal structure of the CRY1-PER2 complex · the same entry in another collection · chain A against A, TM-score 1.00
- P97784 · AlphaFold monomer V2.0 prediction for cryptochrome-1 (P97784) · a predicted model of the same protein · chain A against A, TM-score 0.98
- O15055 · AlphaFold monomer V2.0 prediction for period circadian protein homolog 2 (O15055) · a predicted model of the same protein · chain B against A, TM-score 0.40
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P97784
- Every structure of UniProt O15055
- Elsewhere: RCSB PDB 6OF7 · PDBe 6OF7 · UniProt P97784 · UniProt O15055
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