MolNFT v1 · #159090 · protein
Splayed open prefusion rsv F captured by CR9501 and motavizumab fabs
6OE5 · Fusion glycoprotein F0,FIBRITIN: “Splayed open prefusion rsv F captured by CR9501 and motavizumab fabs”. X-ray diffraction, 11 pockets (best druggability 0.69). MolNFT v1 #159090 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 6OE5
- Type
- protein
- Length
- 1,113 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fusion glycoprotein F0,FIBRITIN; Motavizumab Fab heavy chain; Motavizumab Fab light…
- UniProt
- P03420, P10104
- Pockets
- 11 · best druggability 0.69
Structure
x-ray diffraction · 5 distinct chains · 13% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fusion glycoprotein F0,FIBRITIN | protein | 252 | 38% helix, 27% strand | P03420, P10104 |
| B | Motavizumab Fab heavy chain | protein | 213 | 3% helix, 49% strand | — |
| C | Motavizumab Fab light chain | protein | 211 | 5% helix, 47% strand | — |
| H | CR9501 Fab heavy chain | protein | 225 | 7% helix, 48% strand | — |
| L | CR9501 Fab light chain | protein | 212 | 5% helix, 45% strand | — |
Pockets
11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 63 | 0.69 | 0.95 | 18 | empty |
| 2 | 652 | 0.65 | 0.75 | 72 | empty |
| 3 | 536 | 0.61 | 0.74 | 58 | empty |
| 4 | 221 | 0.49 | 0.75 | 37 | empty |
| 5 | 62 | 0.45 | 0.84 | 25 | empty |
Interfaces
6 interfaces between chains.
- H–L · 2016 Ų buried · 22 hydrogen bonds · protein-protein
- B–C · 1690 Ų buried · 12 hydrogen bonds · protein-protein
- A–H · 602 Ų buried · 12 hydrogen bonds · protein-protein
- A–L · 548 Ų buried · 12 hydrogen bonds · protein-protein
- A–B · 521 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 11 disulfide (disulfide).
Compared structures
- 6OE5 · Splayed open prefusion RSV F captured by CR9501 and motavizumab Fabs · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03420
- Every structure of UniProt P10104
- Elsewhere: RCSB PDB 6OE5 · PDBe 6OE5 · UniProt P03420 · UniProt P10104
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