MolNFT v1 · #158684 · protein
The crystal structure of human MORC3 ATPase-cw in complex with amppnp
6O1E · Morc family cw-type zinc finger protein 3: “The crystal structure of human MORC3 ATPase-cw in complex with amppnp”. X-ray diffraction, 3 ligands (ANP, ZN, MG), 4 pockets (best druggability 0.75). MolNFT v1 #158684 on GenesisL1: 3D…
- PDB
- 6O1E
- Type
- protein
- Length
- 431 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Morc family cw-type zinc finger protein 3
- UniProt
- Q14149
- Ligands
- ANP, ZN, MG
- Pockets
- 4 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 27% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Morc family cw-type zinc finger protein 3 | protein | 431 | 27% helix, 25% strand | Q14149 |
Ligands and binding sites
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · chains A
- ZN · Zinc ion · metal · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 310 | 0.75 | 0.87 | 39 | MG, ANP |
| 2 | 468 | 0.71 | 0.81 | 45 | empty |
| 3 | 246 | 0.63 | 0.81 | 33 | empty |
| 4 | 231 | 0.50 | 0.76 | 34 | empty |
Compared structures
- 6O1E · The crystal structure of human MORC3 ATPase-CW in complex with AMPPNP · the same entry in another collection · chain A against A, TM-score 1.00
- Q14149 · AlphaFold monomer V2.0 prediction for morc family cw-type zinc finger protein 3 (Q14149) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14149
- Elsewhere: RCSB PDB 6O1E · PDBe 6O1E · UniProt Q14149
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