MolNFT v1 · #158681 · protein

Crystal structure of the tir domain G601P mutant from human SARM1, crystal form 1

6O1B · Sterile alpha and tir motif-containing protein 1: “Crystal structure of the tir domain G601P mutant from human SARM1, crystal form 1”. X-ray diffraction, 1 pocket (best druggability 0.42). MolNFT v1 #158681 on GenesisL1: 3D…

PDB: 6O1B
Type: protein
Length: 139 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sterile alpha and tir motif-containing protein 1
UniProt: Q6SZW1
Pockets: 1 · best druggability 0.42

Structure

x-ray diffraction · 1 distinct chain · 50% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sterile alpha and tir motif-containing protein 1	protein	139	50% helix, 14% strand	Q6SZW1

Ligands and binding sites

MES · 2-(N-morpholino)-ethanesulfonic acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	60	0.42	0.82	16	MES

Compared structures

6O1B · Crystal structure of the TIR domain G601P mutant from human SARM1, crystal form 1 · the same entry in another collection · chain A against A, TM-score 1.00
Q6SZW1 · AlphaFold monomer V2.0 prediction for NAD(+) hydrolase SARM1 (Q6SZW1) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6SZW1
Elsewhere: RCSB PDB 6O1B · PDBe 6O1B · UniProt Q6SZW1

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