Crystal structure of the tir domain from the grapevine disease resistance protein RUN1 in complex with NADP+ and bis-tris

Structure

x-ray diffraction · 1 distinct chain · 52% helix, 15% strand (DSSP).

Ligands and binding sites

• A2P · Adenosine-2'-5'-diphosphate · ligand · chains A
• BTB · 2-[bis-(2-hydroxy-ethyl)-amino]-2-hydroxymethyl-propane-1,3-diol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 6O0W · Crystal structure of the TIR domain from the grapevine disease resistance protein RUN1 in… · the same entry in another collection · chain A against A, TM-score 1.00
• V9M398 · AlphaFold monomer V2.0 prediction for disease resistance protein RUN1 (V9M398) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt V9M398
• Elsewhere: RCSB PDB 6O0W · PDBe 6O0W · UniProt V9M398