MolNFT v1 · #158664 · protein

Crystal structure of the tir domain H685A mutant from human SARM1

6O0U · Sterile alpha and tir motif-containing protein 1: “Crystal structure of the tir domain H685A mutant from human SARM1”. X-ray diffraction, 1 pocket (best druggability 0.35). MolNFT v1 #158664 on GenesisL1: 3D structure, binding sites…

PDB: 6O0U
Type: protein
Length: 280 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sterile alpha and tir motif-containing protein 1
UniProt: Q6SZW1
Pockets: 1 · best druggability 0.35

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Sterile alpha and tir motif-containing protein 1	protein	140	46% helix, 15% strand	Q6SZW1

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	63	0.35	0.77	16	empty

Interfaces

1 interface between chains.

A–B · 651 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

6O0U · Crystal structure of the TIR domain H685A mutant from human SARM1 · the same entry in another collection · chain A against A, TM-score 1.00
Q6SZW1 · AlphaFold monomer V2.0 prediction for NAD(+) hydrolase SARM1 (Q6SZW1) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6SZW1
Elsewhere: RCSB PDB 6O0U · PDBe 6O0U · UniProt Q6SZW1

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