MolNFT v1 · #158617 · protein

Low resolution crystal structure of the bacterial multidrug efflux transporter acrb in the presence of cadmium

6NZI · Efflux pump membrane transporter: “Low resolution crystal structure of the bacterial multidrug efflux transporter acrb in the presence of cadmium”. X-ray diffraction, 1 ligand (CD), 12 pockets (best druggability 0.85). MolNFT v1…

PDB: 6NZI
Type: protein
Length: 1,011 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Efflux pump membrane transporter
UniProt: E2QH56
Ligands: CD
Pockets: 12 · best druggability 0.85

Structure

x-ray diffraction · 1 distinct chain · 50% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Efflux pump membrane transporter	protein	1011	50% helix, 15% strand	E2QH56

Ligands and binding sites

CD · Cadmium ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	628	0.85	0.89	86	empty
2	253	0.69	0.85	46	empty
3	481	0.69	0.79	60	empty
4	51	0.65	0.95	19	empty
5	201	0.62	0.82	29	CD

Compared structures

6NZI · Low resolution crystal structure of the bacterial multidrug efflux transporter AcrB in… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt E2QH56
Elsewhere: RCSB PDB 6NZI · PDBe 6NZI · UniProt E2QH56

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