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Low resolution crystal structure of the bacterial multidrug efflux transporter acrb in the presence of cadmium

Analyse Low resolution crystal structure of the bacterial multidrug efflux transporter… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6NZI
Type: protein
Length: 1,011 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Efflux pump membrane transporter
UniProt: E2QH56
Ligands: CD
Pockets: 12 · best druggability 0.85

Structure

x-ray diffraction · 1 distinct chain · 50% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Efflux pump membrane transporter	protein	1011	50% helix, 15% strand	E2QH56

Ligands and binding sites

CD · Cadmium ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	628	0.85	0.89	86	empty
2	253	0.69	0.85	46	empty
3	481	0.69	0.79	60	empty
4	51	0.65	0.95	19	empty
5	201	0.62	0.82	29	CD

Compared structures

6NZI · Low resolution crystal structure of the bacterial multidrug efflux transporter AcrB in… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt E2QH56
Elsewhere: RCSB PDB 6NZI · PDBe 6NZI · UniProt E2QH56

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