MolNFT v1 · #158469 · protein
SARS-coronavirus NSP12 bound to NSP8 co-factor
6NUS: “SARS-coronavirus NSP12 bound to NSP8 co-factor”. Electron microscopy, 1 ligand (ZN), 11 pockets (best druggability 0.65). MolNFT v1 #158469 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6NUS
- Type
- protein
- Length
- 827 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NSP12; NSP8
- UniProt
- P0C6X7, P0C6U8
- Ligands
- ZN
- Pockets
- 11 · best druggability 0.65
Structure
electron microscopy · 2 distinct chains · 44% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NSP12 | protein | 715 | 45% helix, 14% strand | P0C6X7 |
| B | NSP8 | protein | 112 | 39% helix, 28% strand | P0C6U8 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 352 | 0.65 | 0.80 | 47 | empty |
| 2 | 78 | 0.51 | 0.84 | 23 | empty |
| 3 | 196 | 0.51 | 0.77 | 22 | empty |
| 4 | 67 | 0.49 | 0.84 | 18 | empty |
| 5 | 91 | 0.46 | 0.81 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 2331 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 6NUS · SARS-Coronavirus NSP12 bound to NSP8 co-factor · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0C6X7
- Every structure of UniProt P0C6U8
- Elsewhere: RCSB PDB 6NUS · PDBe 6NUS · UniProt P0C6X7 · UniProt P0C6U8
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