MolNFT v1 · #158419 · protein
Cryo-EM structure of the complex between human TBK1 and chicken sting
6NT9 · SERINE/THREONINE-protein kinase TBK1: “Cryo-EM structure of the complex between human TBK1 and chicken sting”. Electron microscopy, 20 pockets (best druggability 0.72). MolNFT v1 #158419 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6NT9
- Type
- protein
- Length
- 1,228 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase TBK1; Stimulator of interferon genes protein
- EC
- 2.7.11.1
- UniProt
- Q9UHD2, A0A1D5P7Q9
- Pockets
- 20 · best druggability 0.72
Structure
electron microscopy · 2 distinct chains · 50% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | SERINE/THREONINE-protein kinase TBK1 (EC 2.7.11.1) | protein | 605 | 51% helix, 13% strand | Q9UHD2 |
| C, D | Stimulator of interferon genes protein | protein | 9 | 0% helix, 0% strand | A0A1D5P7Q9 |
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1188 | 0.72 | 0.76 | 88 | empty |
| 2 | 559 | 0.72 | 0.80 | 54 | empty |
| 3 | 535 | 0.71 | 0.80 | 52 | empty |
| 4 | 371 | 0.66 | 0.80 | 40 | empty |
| 5 | 339 | 0.63 | 0.79 | 39 | empty |
Interfaces
5 interfaces between chains.
- A–B · 1549 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 423 Ų buried · 5 hydrogen bonds · protein-protein
- B–D · 419 Ų buried · 5 hydrogen bonds · protein-protein
- C–B · 231 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 226 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 6NT9 · Cryo-EM structure of the complex between human TBK1 and chicken STING · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UHD2 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase TBK1 (Q9UHD2) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UHD2
- Every structure of UniProt A0A1D5P7Q9
- Elsewhere: RCSB PDB 6NT9 · PDBe 6NT9 · UniProt Q9UHD2 · UniProt A0A1D5P7Q9
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