MolNFT v1 · #158399 · protein
Trk-a in complex with ligand 9
6NSP · High affinity nerve growth factor receptor: “Trk-a in complex with ligand 9”. X-ray diffraction, 1 ligand (L0P), 3 pockets (best druggability 0.67). MolNFT v1 #158399 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6NSP
- Type
- protein
- Length
- 293 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- High affinity nerve growth factor receptor
- EC
- 2.7.10.1
- UniProt
- P04629
- Ligands
- L0P
- Pockets
- 3 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | High affinity nerve growth factor receptor (EC 2.7.10.1) | protein | 293 | 41% helix, 17% strand | P04629 |
Ligands and binding sites
- L0P · N-(8-methyl-2-phenylimidazo[1,2-a]pyridin-3-yl)-2-(3-oxo-2,3-dihydro-4H-1,4-benzothiazin-4-yl)acetamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 454 | 0.67 | 0.79 | 47 | L0P |
| 2 | 148 | 0.59 | 0.83 | 23 | empty |
| 3 | 55 | 0.26 | 0.72 | 15 | empty |
Compared structures
- 6NSP · Trk-a in complex with ligand 9 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04629
- Elsewhere: RCSB PDB 6NSP · PDBe 6NSP · UniProt P04629
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