MolNFT v1 · #158279 · protein

Crystal structure of the sensor domain of the transcriptional regulator hcpr from porphyromonas gingivalis

6NP6 · CRP/FNR family transcriptional regulator: “Crystal structure of the sensor domain of the transcriptional regulator hcpr from porphyromonas gingivalis”. X-ray diffraction, 2 pockets (best druggability 0.60). MolNFT v1 #158279 on…

PDB: 6NP6
Type: protein
Length: 304 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CRP/FNR family transcriptional regulator
UniProt: A0A1R4DW76
Pockets: 2 · best druggability 0.60

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	CRP/FNR family transcriptional regulator	protein	152	39% helix, 27% strand	A0A1R4DW76

Ligands and binding sites

GOL · Glycerol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	245	0.60	0.79	30	GOL
2	210	0.59	0.80	25	GOL

Interfaces

1 interface between chains.

A–B · 620 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

6NP6 · Crystal structure of the sensor domain of the transcriptional regulator HcpR from… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A1R4DW76
Elsewhere: RCSB PDB 6NP6 · PDBe 6NP6 · UniProt A0A1R4DW76

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