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Crystal structure of the sensor domain of the transcriptional regulator hcpr from porphyromonas gingivalis

Analyse Crystal structure of the sensor domain of the transcriptional regulator hcpr… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6NP6
Type: protein
Length: 304 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CRP/FNR family transcriptional regulator
UniProt: A0A1R4DW76
Pockets: 2 · best druggability 0.60

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	CRP/FNR family transcriptional regulator	protein	152	39% helix, 27% strand	A0A1R4DW76

Ligands and binding sites

GOL · Glycerol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	245	0.60	0.79	30	GOL
2	210	0.59	0.80	25	GOL

Interfaces

1 interface between chains.

A–B · 620 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

6NP6 · Crystal structure of the sensor domain of the transcriptional regulator HcpR from… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A1R4DW76
Elsewhere: RCSB PDB 6NP6 · PDBe 6NP6 · UniProt A0A1R4DW76

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