MolNFT v1 · #158221 · protein

Structure of closed state of dihydrofolate reductase from mycobacterium tuberculosis in complex with NADPH and cycloguanil

6NNH: “Structure of closed state of dihydrofolate reductase from mycobacterium tuberculosis in complex with NADPH…”. X-ray diffraction, 4 ligands (1CY, NDP, CO). MolNFT v1 #158221 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 6NNH
Type: protein
Length: 318 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P9WNX1
Ligands: 1CY, NDP, CO, SO4

Structure

x-ray diffraction · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	—	protein	159	—	P9WNX1

Ligands and binding sites

1CY · 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine · ligand · 2 copies · chains A, B
NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · 2 copies · chains A, B
CO · Cobalt (II) ion · metal · 2 copies · chains A, B
SO4 · Sulfate ion · ion · 5 copies · chains A, B
GOL · Glycerol · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6NNH · Structure of Closed state of Dihydrofolate reductase from Mycobacterium tuberculosis in… · the same entry in another collection · chain A against A, TM-score 1.00
P9WNX1 · AlphaFold monomer V2.0 prediction for dihydrofolate reductase (P9WNX1) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P9WNX1
Elsewhere: RCSB PDB 6NNH · PDBe 6NNH · UniProt P9WNX1

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