MolNFT v1 · #158170 · protein
Selective inhibition of carbonic anhydrase IX activity, using compound slc-149, displays limited anticancer effects in breast cancer cell lines
6NM0: “Selective inhibition of carbonic anhydrase IX activity, using compound slc-149, displays limited anticancer…”. X-ray diffraction, 2 ligands (KRY, ZN). MolNFT v1 #158170 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6NM0
- Type
- protein
- Length
- 257 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P00918
- Ligands
- KRY, ZN
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 257 | — | P00918 |
Ligands and binding sites
- KRY · 4-[3-(2,4-difluorophenyl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]benzene-1-sulfonamide · ligand · chains A
- ZN · Zinc ion · metal · chains A
- DMS · Dimethyl sulfoxide · additive · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6NM0 · Selective inhibition of carbonic anhydrase IX activity, using compound SLC-149, displays… · the same entry in another collection · chain A against A, TM-score 1.00
- P00918 · AlphaFold monomer V2.0 prediction for carbonic anhydrase 2 (P00918) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00918
- Elsewhere: RCSB PDB 6NM0 · PDBe 6NM0 · UniProt P00918
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