MolNFT v1 · #158079 · protein
Crystal structure of the motor domain of human kinesin family member 22
6NJE · Kinesin-like protein KIF22: “Crystal structure of the motor domain of human kinesin family member 22”. X-ray diffraction, 4 ligands (ADP, MG, NA), 4 pockets (best druggability 0.51). MolNFT v1 #158079 on GenesisL1: 3D structure…
- PDB
- 6NJE
- Type
- protein
- Length
- 297 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kinesin-like protein KIF22
- UniProt
- Q14807
- Ligands
- ADP, MG, NA, CL
- Pockets
- 4 · best druggability 0.51
Structure
x-ray diffraction · 1 distinct chain · 30% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Kinesin-like protein KIF22 | protein | 297 | 30% helix, 29% strand | Q14807 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · chains A
- MG · Magnesium ion · metal · chains A
- NA · Sodium ion · metal · chains A
- CL · Chloride ion · ion · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 141 | 0.51 | 0.80 | 32 | MG |
| 2 | 74 | 0.42 | 0.80 | 17 | empty |
| 3 | 123 | 0.36 | 0.73 | 28 | CL |
| 4 | 77 | 0.35 | 0.76 | 14 | empty |
Compared structures
- 6NJE · Crystal structure of the motor domain of human kinesin family member 22 · the same entry in another collection · chain A against A, TM-score 1.00
- Q14807 · AlphaFold monomer V2.0 prediction for kinesin-like protein KIF22 (Q14807) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14807
- Elsewhere: RCSB PDB 6NJE · PDBe 6NJE · UniProt Q14807
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