Research workbench
Crystal structure of the motor domain of human kinesin family member 22
Analyse Crystal structure of the motor domain of human kinesin family member 22 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6NJE
- Type
- protein
- Length
- 297 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kinesin-like protein KIF22
- UniProt
- Q14807
- Ligands
- ADP, MG, NA, CL
- Pockets
- 4 · best druggability 0.51
Structure
x-ray diffraction · 1 distinct chain · 30% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Kinesin-like protein KIF22 | protein | 297 | 30% helix, 29% strand | Q14807 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · chains A
- MG · Magnesium ion · metal · chains A
- NA · Sodium ion · metal · chains A
- CL · Chloride ion · ion · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 141 | 0.51 | 0.80 | 32 | MG |
| 2 | 74 | 0.42 | 0.80 | 17 | empty |
| 3 | 123 | 0.36 | 0.73 | 28 | CL |
| 4 | 77 | 0.35 | 0.76 | 14 | empty |
Compared structures
- 6NJE · Crystal structure of the motor domain of human kinesin family member 22 · the same entry in another collection · chain A against A, TM-score 1.00
- Q14807 · AlphaFold monomer V2.0 prediction for kinesin-like protein KIF22 (Q14807) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14807
- Elsewhere: RCSB PDB 6NJE · PDBe 6NJE · UniProt Q14807
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