MolNFT v1 · #157961 · protein
MBTD1 mbt repeats
6NFX · Mbt domain-containing protein 1,ENHANCER of polycomb…: “MBTD1 mbt repeats”. X-ray diffraction, 2 ligands (NA, UNX), 5 pockets (best druggability 0.80). MolNFT v1 #157961 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6NFX
- Type
- protein
- Length
- 429 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mbt domain-containing protein 1,ENHANCER of polycomb homolog 1
- UniProt
- Q05BQ5, Q9H2F5
- Ligands
- NA, UNX
- Pockets
- 5 · best druggability 0.80
Structure
x-ray diffraction · 1 distinct chain · 19% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mbt domain-containing protein 1,ENHANCER of polycomb homolog 1 | protein | 429 | 19% helix, 30% strand | Q05BQ5, Q9H2F5 |
Ligands and binding sites
- NA · Sodium ion · metal · chains A
- UNX · Unknown atom or ion · ion · 38 copies · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 753 | 0.80 | 0.83 | 71 | UNX |
| 2 | 82 | 0.47 | 0.81 | 16 | empty |
| 3 | 66 | 0.34 | 0.76 | 19 | empty |
| 4 | 57 | 0.30 | 0.76 | 12 | empty |
| 5 | 50 | 0.27 | 0.74 | 14 | UNX |
Compared structures
- 6NFX · MBTD1 MBT repeats · the same entry in another collection · chain A against A, TM-score 1.00
- Q05BQ5 · AlphaFold monomer V2.0 prediction for mbt domain-containing protein 1 (Q05BQ5) · a predicted model of the same protein · chain A against A, TM-score 0.95
- Q9H2F5 · AlphaFold monomer V2.0 prediction for enhancer of polycomb homolog 1 (Q9H2F5) · a predicted model of the same protein · chain A against A, TM-score 0.22
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q05BQ5
- Every structure of UniProt Q9H2F5
- Elsewhere: RCSB PDB 6NFX · PDBe 6NFX · UniProt Q05BQ5 · UniProt Q9H2F5
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