MolNFT v1 · #157879 · protein

2.60 ångström resolution crystal structure of periplasmic binding and sugar binding domain of laci family protein from klebsiella pneumoniae.

6NDI · Transcriptional regulator: “2.60 ångström resolution crystal structure of periplasmic binding and sugar binding domain of laci family…”. X-ray diffraction, 4 pockets (best druggability 0.73). MolNFT v1 #157879 on GenesisL1: 3D…

PDB: 6NDI
Type: protein
Length: 544 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcriptional regulator
UniProt: A0A2W0LW10
Pockets: 4 · best druggability 0.73

Structure

x-ray diffraction · 2 distinct chains · 36% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcriptional regulator	protein	273	36% helix, 23% strand	A0A2W0LW10
B	Transcriptional regulator	protein	271	36% helix, 23% strand	A0A2W0LW10

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	103	0.73	0.94	20	empty
2	446	0.72	0.82	67	empty
3	308	0.72	0.85	36	empty
4	79	0.35	0.75	13	empty

Interfaces

1 interface between chains.

A–B · 1738 Å² buried · 17 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 10 modified (engineered).

Compared structures

6NDI · Crystal Structure of the Sugar Binding Domain of LacI Family Protein from Klebsiella… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A2W0LW10
Elsewhere: RCSB PDB 6NDI · PDBe 6NDI · UniProt A0A2W0LW10

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