MolNFT v1 · #157858 · protein
Cryo-EM structure of NLRP6 pyd filament
6NCV · Nacht, lrr and pyd domains-containing protein 6: “Cryo-EM structure of NLRP6 pyd filament”. Electron microscopy, 20 pockets (best druggability 0.66). MolNFT v1 #157858 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6NCV
- Type
- protein
- Length
- 1,911 residues
- Chains
- 21
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nacht, lrr and pyd domains-containing protein 6
- UniProt
- P59044
- Pockets
- 20 · best druggability 0.66
Structure
electron microscopy · 1 distinct chain · 57% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, V | Nacht, lrr and pyd domains-containing protein 6 | protein | 91 | 57% helix, 0% strand | P59044 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 377 | 0.66 | 0.80 | 38 | empty |
| 2 | 372 | 0.66 | 0.80 | 38 | empty |
| 3 | 386 | 0.66 | 0.79 | 38 | empty |
| 4 | 380 | 0.65 | 0.80 | 41 | empty |
| 5 | 360 | 0.65 | 0.80 | 38 | empty |
Interfaces
51 interfaces between chains.
- E–F · 474 Ų buried · 3 hydrogen bonds · protein-protein
- T–V · 472 Ų buried · 3 hydrogen bonds · protein-protein
- Q–R · 471 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 470 Ų buried · 3 hydrogen bonds · protein-protein
- L–M · 470 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 6NCV · Cryo-EM structure of NLRP6 PYD filament · the same entry in another collection · chain V against V, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P59044
- Elsewhere: RCSB PDB 6NCV · PDBe 6NCV · UniProt P59044
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