UniProt P59044

NACHT, LRR and PYD domains-containing protein 6 (P59044)

NACHT, LRR and PYD domains-containing protein 6 (UniProt P59044): 4 experimental structures and 1 predicted model on GenesisL1, 67 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: P59044
Protein: NACHT, LRR and PYD domains-containing protein 6
Experimental structures: 4
Predicted models: 1
Pockets: 67 · 5 records with a druggable one

Structures

5 records of P59044 in the MolNFT archive: 4 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
6NCV	Cryo-EM structure of NLRP6 PYD filament	electron microscopy	A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, V	—	20 (best 0.66)
6NCV	Cryo-EM structure of NLRP6 pyd filament	electron microscopy	A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, V	—	20 (best 0.66)
6NDJ	Crystal structure of human NLRP6 PYD domain with MBP fusion	x-ray diffraction	A, B	—	7 (best 0.56)
6NDJ	Crystal structure of human NLRP6 pyd domain with mbp fusion	x-ray diffraction	A, B	—	7 (best 0.56)
P59044	AlphaFold monomer V2.0 prediction for nacht, lrr and pyd domains- containing protein 6 (P59044)	predicted	A	—	13 (best 0.74)

Experiment against prediction

6NCV chain A against the predicted model P59044: TM-score 0.91, RMSD 1.14 Å
6NCV chain A against the predicted model P59044: TM-score 0.91, RMSD 1.14 Å
6NDJ chain B against the predicted model P0AEX9: TM-score 0.69, RMSD 3.58 Å
6NDJ chain A against the predicted model P0AEX9: TM-score 0.68, RMSD 3.74 Å
6NDJ chain A against the predicted model P59044: TM-score 0.30, RMSD 7.01 Å
6NDJ chain A against the predicted model P59044: TM-score 0.30, RMSD 7.01 Å
6NDJ chain B against the predicted model P59044: TM-score 0.28, RMSD 7.24 Å
6NDJ chain B against the predicted model P59044: TM-score 0.28, RMSD 7.24 Å

Elsewhere

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