MolNFT v1 · #157811 · protein
Horse liver alcohol dehydrogenase determined using single-particle cryo-EM at 200 kev
6NBB · Alcohol dehydrogenase E chain: “Horse liver alcohol dehydrogenase determined using single-particle cryo-EM at 200 kev”. Electron microscopy, 2 ligands (NAD, ZN), 4 pockets (best druggability 0.72). MolNFT v1 #157811 on GenesisL1: 3D…
- PDB
- 6NBB
- Type
- protein
- Length
- 748 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alcohol dehydrogenase E chain
- EC
- 1.1.1.1
- UniProt
- P00327
- Ligands
- NAD, ZN
- Pockets
- 4 · best druggability 0.72
Structure
electron microscopy · 1 distinct chain · 26% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Alcohol dehydrogenase E chain (EC 1.1.1.1) | protein | 374 | 26% helix, 25% strand | P00327 |
Ligands and binding sites
- NAD · Nicotinamide-adenine-dinucleotide · ligand · 2 copies · chains A, B
- ZN · Zinc ion · metal · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 467 | 0.72 | 0.81 | 66 | NAD |
| 2 | 303 | 0.71 | 0.84 | 47 | NAD |
| 3 | 410 | 0.69 | 0.81 | 56 | empty |
| 4 | 136 | 0.49 | 0.79 | 34 | empty |
Interfaces
1 interface between chains.
- A–B · 1713 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 6NBB · Horse liver alcohol dehydrogenase determined using single-particle cryo-EM at 200 keV · the same entry in another collection · chain A against A, TM-score 1.00
- P00327 · AlphaFold monomer V2.0 prediction for alcohol dehydrogenase E chain (P00327) · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00327
- Elsewhere: RCSB PDB 6NBB · PDBe 6NBB · UniProt P00327
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