MolNFT v1 · #157738 · protein
Crystal structure of the human cell polarity protein lethal giant larvae 2 (LGL2). apkc phosphorylated, crystal form 3.
6N8S · LETHAL(2) giant larvae protein homolog 2: “Crystal structure of the human cell polarity protein lethal giant larvae 2 (LGL2). apkc phosphorylated…”. X-ray diffraction, 15 pockets (best druggability 0.83). MolNFT v1 #157738 on…
- PDB
- 6N8S
- Type
- protein
- Length
- 1,664 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- LETHAL(2) giant larvae protein homolog 2
- UniProt
- Q6P1M3
- Pockets
- 15 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | LETHAL(2) giant larvae protein homolog 2 | protein | 834 | 7% helix, 45% strand | Q6P1M3 |
| D | LETHAL(2) giant larvae protein homolog 2 | protein | 830 | 6% helix, 47% strand | Q6P1M3 |
Pockets
15 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1087 | 0.83 | 0.84 | 82 | empty |
| 2 | 1131 | 0.82 | 0.83 | 88 | empty |
| 3 | 1117 | 0.81 | 0.82 | 88 | empty |
| 4 | 910 | 0.79 | 0.82 | 67 | empty |
| 5 | 1139 | 0.79 | 0.81 | 60 | empty |
Interfaces
1 interface between chains.
- A–D · 1823 Ų buried · 40 hydrogen bonds · protein-protein
Compared structures
- 6N8S · Crystal structure of the human cell polarity protein Lethal Giant Larvae 2 (Lgl2). aPKC… · the same entry in another collection · chain A against A, TM-score 1.00
- Q6P1M3 · AlphaFold monomer V2.0 prediction for llgl scribble cell polarity complex component 2… · a predicted model of the same protein · chain D against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6P1M3
- Elsewhere: RCSB PDB 6N8S · PDBe 6N8S · UniProt Q6P1M3
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