MolNFT v1 · #157735 · protein
Crystal structure of the human cell polarity protein lethal giant larvae 2 (LGL2). unphosphorylated, crystal form 1.
6N8P · LETHAL(2) giant larvae protein homolog 2: “Crystal structure of the human cell polarity protein lethal giant larvae 2 (LGL2). unphosphorylated, crystal…”. X-ray diffraction, 1 ligand (CL), 8 pockets (best druggability 0.83). MolNFT…
- PDB
- 6N8P
- Type
- protein
- Length
- 827 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- LETHAL(2) giant larvae protein homolog 2
- UniProt
- Q6P1M3
- Ligands
- CL
- Pockets
- 8 · best druggability 0.83
Structure
x-ray diffraction · 1 distinct chain · 6% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | LETHAL(2) giant larvae protein homolog 2 | protein | 827 | 6% helix, 47% strand | Q6P1M3 |
Ligands and binding sites
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1091 | 0.83 | 0.84 | 76 | CL |
| 2 | 1050 | 0.79 | 0.81 | 57 | empty |
| 3 | 247 | 0.67 | 0.84 | 28 | empty |
| 4 | 327 | 0.65 | 0.80 | 49 | empty |
| 5 | 54 | 0.41 | 0.82 | 18 | empty |
Compared structures
- 6N8P · Crystal structure of the human cell polarity protein Lethal Giant Larvae 2 (Lgl2).… · the same entry in another collection · chain A against A, TM-score 1.00
- Q6P1M3 · AlphaFold monomer V2.0 prediction for llgl scribble cell polarity complex component 2… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6P1M3
- Elsewhere: RCSB PDB 6N8P · PDBe 6N8P · UniProt Q6P1M3
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