MolNFT v1 · #157649 · protein
Crystal structure of mouse SMCHD1 hinge domain
6N64 · Structural maintenance of chromosomes flexible hinge…: “Crystal structure of mouse SMCHD1 hinge domain”. X-ray diffraction, 13 pockets (best druggability 0.83). MolNFT v1 #157649 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 6N64
- Type
- protein
- Length
- 1,071 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Structural maintenance of chromosomes flexible hinge domain-containing protein 1…
- EC
- 3.6.1.-
- UniProt
- Q6P5D8
- Pockets
- 13 · best druggability 0.83
Structure
x-ray diffraction · 7 distinct chains · 40% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (EC 3.6.1.-) | protein | 170 | 38% helix, 12% strand | Q6P5D8 |
| B | Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (EC 3.6.1.-) | protein | 173 | 37% helix, 12% strand | Q6P5D8 |
| C, D | Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (EC 3.6.1.-) | protein | 175 | 39% helix, 13% strand | Q6P5D8 |
| E | Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (EC 3.6.1.-) | protein | 173 | 38% helix, 13% strand | Q6P5D8 |
| F | Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (EC 3.6.1.-) | protein | 172 | 41% helix, 11% strand | Q6P5D8 |
| G | Uncharacterized peptide from structural maintenance of chromosomes flexible hinge domain-containing protein 1 (EC 3.6.1.-) | protein | 12 | 67% helix, 0% strand | — |
| H | Uncharacterized peptide from structural maintenance of chromosomes flexible hinge domain-containing protein 1 (EC 3.6.1.-) | protein | 21 | 90% helix, 0% strand | — |
Pockets
13 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1027 | 0.83 | 0.84 | 89 | empty |
| 2 | 1058 | 0.82 | 0.84 | 88 | empty |
| 3 | 1031 | 0.81 | 0.82 | 81 | empty |
| 4 | 404 | 0.60 | 0.76 | 42 | empty |
| 5 | 178 | 0.58 | 0.81 | 31 | empty |
Interfaces
11 interfaces between chains.
- E–F · 1690 Ų buried · 25 hydrogen bonds · protein-protein
- C–D · 1683 Ų buried · 22 hydrogen bonds · protein-protein
- A–B · 1680 Ų buried · 21 hydrogen bonds · protein-protein
- A–F · 591 Ų buried · 13 hydrogen bonds · protein-protein
- C–E · 246 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 24 modified, 1 disulfide (engineered, disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6P5D8
- Elsewhere: RCSB PDB 6N64 · PDBe 6N64 · UniProt Q6P5D8
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