MolNFT v1 · #157557 · protein

Segb, conformation of tdp-43 low complexity domain segment a

6N3C · Tar DNA-binding protein 43: “Segb, conformation of tdp-43 low complexity domain segment a”. Electron microscopy, 2 pockets (best druggability 0.69). MolNFT v1 #157557 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6N3C
Type: protein
Length: 640 residues
Chains: 20
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tar DNA-binding protein 43
UniProt: Q13148
Pockets: 2 · best druggability 0.69

Structure

electron microscopy · 1 distinct chain · 0% helix, 63% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	Tar DNA-binding protein 43	protein	32	0% helix, 63% strand	Q13148

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	245	0.69	0.86	46	empty
2	271	0.69	0.85	40	empty

Interfaces

88 interfaces between chains.

A–E · 1191 Å² buried · 42 hydrogen bonds · protein-protein
O–S · 1190 Å² buried · 42 hydrogen bonds · protein-protein
A–K · 1190 Å² buried · 42 hydrogen bonds · protein-protein
C–G · 1190 Å² buried · 42 hydrogen bonds · protein-protein
I–M · 1189 Å² buried · 42 hydrogen bonds · protein-protein

Compared structures

6N3C · SegB, conformation of TDP-43 low complexity domain segment A · the same entry in another collection · chain T against T, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13148
Elsewhere: RCSB PDB 6N3C · PDBe 6N3C · UniProt Q13148

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